"Trump's ignorant hate speech belongs in medieval times - not the 21st century UN - unworthy of a reply," Zarif tweeted on Tuesday.
“Fake empathy for Iranians fools no one," he stressed.
Donald Trump's first major speech at the United Nations has been strongly denounced by several of the member nations he singled out for criticism.
Reacting to the speech, , Swedish Foreign Minister Margot Wallstrom, has also said: "It was the wrong speech, at the wrong time, to the wrong audience."
Ben Rhodes, an adviser to former Democratic President Barack Obama, said Trump was upending international order with threats of war and attacks on diplomacy.
Trump repeated baseless allegations against Tehran, accusing it of engaging in “destabilizing activities” in the region.
The US and some of its regional allies, including Saudi Arabia, have been staunch supporters of Takfiri terrorists in the Muslim states of Syria and Iraq.
Tehran has, meanwhile, been praised for its support for anti-terrorism efforts by the governments in Damascus and Baghdad.
The Takfiri terrorists of Daesh were initially trained by the CIA in Jordan in 2012 to destabilize the Syrian government.
On North Korea, Trump said, "If [the US] is forced to defend itself or its allies, we will have no choice but to totally destroy North Korea" – a threat as unequivocal as this forum has heard and one that spread concerned murmurs throughout the hall.
It was another example of the slightly confused philosophy behind Trump's foreign policy – one in which he advocates non-interference at one moment, then threatens to unleash US military might the next.
Iranian President Hassan Rouhani also earlier said that the United States has failed to remain committed to any of its international obligations, stressing that Washington is not a reliable country.
“Today, you can see that the US is trampling on its agreements with Cuba and other countries one after the other,” Rouhani said in a meeting with Bolivia's President Evo Morales in New York on Monday.
Rouhani pointed to the White House's intention to undermine the historic nuclear deal, known as the Joint Comprehensive Plan of Action (JCPOA), reached between Iran and the P5+1 group of countries, and said, “On the nuclear agreement, the Americans are looking for excuses and the world can see what Iran has repeatedly announced is true; that the US is not reliable.”
Iran and the five permanent members of the United Nations Security Council – the United States, France, Britain, Russia and China – plus Germany signed the nuclear agreement on July 14, 2015 and started implementing it on January 16, 2016.
Under the JCPOA, Iran undertook to put limitations on its nuclear program in exchange for the removal of nuclear-related sanctions imposed against Tehran.